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Ulcer Treatment

Page 2
Peptic Ulcer Disease

Treatment for Peptic Ulcer
Histamine 2 (H2) Receptor Blockers
Within the parietal cells of the stomach is the ATPase pump, also called the proton pump, which releases hydrochloric acid. This pump is activated when histamine stimulates H2 receptors. H2 blockers prevent histamine from binding to H2 receptors and activating the ATPase pump, thereby reducing the amount of acid that is released. Drugs in this class are available in lower non prescription doses and higher precription doses.
  • Cimetidine Oral (Tagamet HB, Tagamet Oral)
  • Famotidine Oral (Pepcid AC, Pepcid Oral)
  • Nizatidine (Axid, Axid AR)
  • Ranitidine Oral (Zantac AR, Zantac Oral)


Proton Pump Inhibitors (PPIs)
Hydrochloric acid is released by the proton pump (ATPase pump) located within the parietal cells of the stomach. Proton pump inhibitors (PPIs) bind to the ATPase enzyme, suppressing gastric acid output. They relieve pain and heal peptic ulcers faster than H2 blockers but are typically more expensive.
  • Esomeprazole (Nexium)
  • Lansoprazole (Prevacid)
  • Omeprazole (Prilosec)
  • Pantoprazole (Protonix)
  • Rabeprazole (Aciphex)
Ulcers take time to heal. Take your medicines even if the pain goes away. If these medicines make you feel sick or dizzy, or cause diarrhea or headaches, your doctor can change your medicines. If prescription or non prescription nonsteroidal anti-inflammatory drugs (NSAIDs) or pain relievers such as aspirin, ibuprofen caused your peptic ulcer, you'll need to stop taking them. If you smoke, quit. Smoking slows healing of ulcers.

If you have a peptic ulcer, taking antacids will stop the stomach acids from working, reduce the pain and help the ulcers heal. You can buy antacids at any grocery store or drugstore. But you must take them several times a day. Also, antacids won't kill the bacteria, you must take antibiotics the doctor prescribes for you.

Peptic ulcers can come back if you stop taking your antibiotic too soon, not all the bacteria will be gone and not all the sores will be healed. If you still smoke or take NSAIDs, your ulcers may come back. In many cases, medicine heals ulcers. You may need surgery if your ulcers don't heal, or keep coming back, perforate, bleed, or obstruct the stomach or duodenum (the first part of the small intestine). Surgery can remove the ulcers and reduce the amount of acid your stomach makes.

For more information about Helicobacter pylori (H. pylori) infection and ulcers, see your health care provider or call Toll Free 1-888-MY-ULCER.

Page 1 Ulcer Treatment
Page 2 Ulcer Treatment


References:
www.cdc.gov/ulcer/

Proton Pump Inhibitors
Nexium - Esomeprazole
Aciphex - Rabeprazole
Prevacid - Lansoprazole
Prilosec - Omeprazole
Prilosec OCT
Protonix - Pantoprazole

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