Most people with primary biliary cirrhosis are diagnosed before symptoms begin. The first and most common symptoms people with this condition experience are:

• A general feeling of tiredness, or fatigue.
• Pruritus – itchy skin – and darkened skin in itchy areas due to scratching.

Other symptoms may develop, including:

• Dry eyes and mouth.
• Jaundice – darkening of the urine and yellowing of the skin and whites of the eyes – which occurs when the diseased liver does not remove enough bilirubin from the blood. Bilirubin is the pigment that gives bile its reddish-yellow color.

Source: digestive.niddk.nih.gov – December 2008