The disorders mentioned below can slow the movement of stool through the colon, rectum, or anus causing constipation.

Neurological Disorders

• Multiple Sclerosis (MS)
• Parkinson’s Disease (PD) – Parkinson’s disease is a brain disorder that leads to shaking, stiffness, and difficulty with walking, balance, and coordination.
• Chronic Idiopathic Intestinal Pseudo-Obstruction
• Stroke
• Spinal Cord Injury

Metabolic and Endocrine Conditions

• Diabetes – A condition in which a person has high blood sugar, also called hyperglycemia, because the body cannot use blood glucose, or blood sugar, for energy.
• Hypothyroidism – When not enough thyroid hormone is made to meet the body’s needs and many of the body’s functions slow down. Also called underactive thyroid. Symptoms include weight gain, constipation, dry skin, and sensitivity to the cold.
• Uremia
• Hypercalcemia (HY-per-kal-SEE-mee-uh) – An abnormally high amount of calcium in the blood.
• Poor glycemic control (glucose in the blood).

Systemic Disorders

• Amyloidosis
• Lupus
• Scleroderma – Some types of scleroderma lead to hard, tight skin, other types affect blood vessels and major organs, such as the heart, lungs, and kidneys.

Source: digestive.niddk.nih.gov – July 2007